Familial Tako-tsubo Cardiomyopathy: Clinical and Echocardiographic Features Including Magnetic Resonance Imaging Findings
Tahir Tak, MD, PhD; Umesh Sharma, MD, MBA; Swetha Karturi, MD; S. Michael Gharacholou, MD
Introduction: Tako-tsubo cardiomyopathy (TCM) is being recognized more frequently; and a familial form of this diagnosis has been suspected but is less well-established.
Case: A 75-year-old patient with a family history of TCM was admitted with suspected ST-segment elevation myocardial infarction. Transthoracic echocardiography showed apical dyskinesis with hyperdynamic basal walls and a left ventricular ejection fraction (LVEF) of 25%. Repeat echocardiography showed normal LVEF of 60% ejection fraction. Cardiac catheterization showed no significant stenosis.
Discussion: TCM is characterized by transient systolic left ventricular dysfunction. A few cases of familial TCM have been reported in the literature and a genetic component is suspected.
Conclusions: Although there has been a paucity of data, familial cases of TCM have been reported. This case study addresses TCM and the familial occurrence of the syndrome, which may have a genetic basis.
Author Affiliations: Departments of Cardiovascular Diseases (Tak) and Hospital Medicine (Sharma, Karturi), Mayo Clinic Health System – Franciscan Healthcare, La Crosse, Wis; Mayo Clinic, Rochester, Minn (Tak); Department of Cardiovascular Diseases, Mayo Clinic, Jacksonville, Fla (Gharacholou).
Corresponding Author: Tahir Tak, MD, PhD, FACC, Cardiovascular Diseases, Mayo Clinic, 200 First St SW, Rochester, MN 55905; phone 507.284.2941; fax 507.266.7929; email firstname.lastname@example.org.